Human LXRα variants

Details Human LXRα variants Human LXRα variants

2008-03-11

2008-03-11

Carlson, Karen Cochrane (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

Reexamination Certificate

active

10921023

ABSTRACT:
This invention provides novel human LXRα variant polypeptides and nucleic acids encoding such polypeptides. This invention also provides the therapeutic, diagnostic, and research utilities as well as the production of such polynucleotides and polypeptides. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

REFERENCES:
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patent: 2003/0073623 (2003-04-01), Drmanac et al.
patent: 1 371 662 (2003-12-01), None
patent: WO 96/21726 (1996-07-01), None
patent: WO 01/57276 (2001-08-01), None
patent: WO 0157272 (2001-09-01), None
patent: WO 0157277 (2001-09-01), None
patent: WO 01/86003 (2001-11-01), None
patent: WO 02/077229 (2002-10-01), None
patent: WO 03/016475 (2003-02-01), None
patent: WO 03/059884 (2003-07-01), None
patent: WO 03/060078 (2003-07-01), None
patent: WO 2004/011604 (2004-02-01), None
patent: WO 2004/023973 (2004-03-01), None
GenCore vesrion 5.1.6, pp. 1-2 for SEQ ID No. 16.
GenCore version 5.1.6, pp. 1-2 for SEQ ID No. 17.
SCORE Search Results for SEQ ID No. 3, pp. 1-14.
Database Geneseq XP-002308605,“Human diagnostic and therapeutic polynucleotide Seq ID No. 577”, accession No. ACN41702.
Database Geneseq XP002308608, “Human protein Q13133, Seq ID No. 8105”, accession No. ADE62176.
Database EMBL XP-002319711, EPO proteins, “Sequence 34095 from Patent WO0186003”, CQ 322990.
Database EMBL XP-002319712, “Homo sapiensnuclear receptor subfamily 1, group H, member 3, mRNA (cDNA clone MGC:10474 Image:3957848), complete cds”, accession No. BC008819.
Database Geneseq XP-002319713, “Human bone marrow expressed probe encoded protein SEQ ID No. 34898”, accession No. AAM74592.
Database EMBL XP-002319714, “Human diagnostic and therapeutic polynucleotide Seq. ID No. 576”, accession No. ACN41702.
Database EMBL XP-002319715, “7a55f01.x1 NCI CGAP GC6Homo sapienscDNA clone Image: 32226493′ similar to TR:Q13133 Q13133 Nuclear orphan receptor LXR-alpha; mRNA sequence”, accession No. BE671656.
Database Genseq XP-002319716, “Human genome-derived single exon probe from lung Seq ID No. 8759,” accession No. ABS08768.
Database EMBL XP-002319717,“Sequence 8516 from Patent WO0157276”, accession No. CQ138494.
Database EMBL XP-002319718, “Homo sapienschromosome 11, clone RP11-17G12, complete sequence”, accession No. ACO18410.
Edwards et al., “LXRs: Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis”, Vasc. Pharmacol. 38: 249-256 (2002).
Frias et al., “A major isoform of the maize plasma membrane H+-ATPase: characterization and induction by auxin in coleoptiles”, 8:1533-1544 (1996).
Peet et al., “The LXRs: a new class of oxysterol receptors,” 8:571-575 (1998).
Willy et al., “LXR, a nuclear receptor that defines a distinct retinoid response pathway,” Genes & Development 9:1033-1045 (1995).
Written Opinion of the International Searching Authority and International Search Report.

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