Human liver regeneration associated protein and the use thereof

Details Human liver regeneration associated protein and the use thereof Human liver regeneration associated protein and the use thereof

2003-12-31

2010-06-22

Bowman, Amy (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S024300, C536S024310, C536S024330, C514S04400A, C435S320100

Reexamination Certificate

active

07741468

ABSTRACT:
This invention provides a novel human liver regeneration associated protein hLRTM4 and the polynucleotide which encodes the hLRTM4 protein. Furthermore, this invention provides a method of preparing and using hLRTM4 protein and its polynucleotides. hLRTM4 protein can be used to treat liver injury, and its antagonists (e.g. antisense nucleic acids and antibodies) can be used to treat hepatocellular carcinoma. This invention also provides the corresponding pharmaceutical compositions.

REFERENCES:
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patent: 1367179 (2002-09-01), None
patent: WO 01/47944 (2001-07-01), None
patent: WO-2004/060914 (2004-07-01), None
NCI-CGAP EST sequence (http://www.ncbi.nlm.nih.gov
cicgap, Accession AI241478, mRNA linear EST Dec. 1, 1998, (see sequence results in Score, search labeled “20081218—105428—us-10-541-247-1.sl.rst”, result #12)). Sequence result is supplied within the office action.
International Search Report for PCT/CN03/01154 mailed on May 13, 2004.
Wice, B.M. et al., NCBI Register No. U31449.1 GI:953238, Aug. 1995.
Z. Liu et al., NCBI Register No. AF205717.1 GI:11493836, Mar. 2001.

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