Human LIG-1 homolog (HLIG-1)

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 536 231, 536 235, C12N 1512, C12N 1585, C12N 1563, C07H 2104

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06046030&

ABSTRACT:
HLIG-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLIG-1 polypeptides and polynucleotides in the design of protocols for the treatment of neurological disorders such as Alzheimer's disease, multiple sclerosis and abnormal neural development; endocrine disorders such as diabetes; and heart disease, among others and diagnostic assays for such conditions.

REFERENCES:
GenBank Accession #D78572.
GenBank Accession #X53959.
GenBank Accession #P35859.
GenBank Accession #U11052.
GenBank Accession #X66494.
Y. Suzuki, et al., "cDNA Cloning of a Novel Membrane Glycoprotein That Is Expressed specifically in Glial Cells in the Mouse Brain", J. Biol. Chem., vol. 271, pp. 22522-22527 (1996).
J. Dai, et al., "Molecular Cloning Of The Acid-Labile Subunit Of The Rat Insulin-Like Growth Factor Binding Protein Complex", Biochem Biophys. Res. Commun., vol. 188, pp. 304-309 (1992).
J.M. Rothberg, et al., "slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains" Genes & Development, vol. 4, pp. 2169-2187 (1990).
R.E. Nelson et al., "Peroxidasin: a novel enzyme-matrix protein of Drosophila development", EMBO J., vol. 13, pp. 3438-3447 (1994).
W.Mayser et al., "Primary structure and functional expression of a choline transporter expressed in the rat nervous system", FEBS Lett., vol. 305, pp. 31-36 (1992).
Human Genome Sciences EST #231054.
Genbank Accession #V04445.
Lewin, Genes IV (1990) Oxford University Press, NY pp. 75-77.
Schlesinger (ed); George et al, "Current Methods in Sequence Comparison and Analysis" Macromolecular Sequencing and Synthesis, (1988) 127-149.

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