Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1995-02-28
1997-10-14
Hendricks, Keith D.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
435194, C12N 912, A61K 3845
Patent
active
056769458
ABSTRACT:
A novel protein kinase, leucine-zipper protein kinase, 668 amino acids in length is provided by the present invention. This protein kinase is localized to the human brain. Nucleic acid sequences encoding the protein kinase are also provided.
REFERENCES:
Asano, T. et al., "Domains Responsible for the Differential Targeting of Glucose Transporter Isoforms", J. Biol. Chem. 1992, 267, 19636-19641.
Forman, B. et al, "A Domain Containing Leucine-Zipper-Like Motifs Mediate Novel In Vivo Interactions Between the Thyroid Hormone and Retinoic Acid Receptors", Molecular Endocrinology 1989, 3, 1610-1626.
Gabathuler and Kvist, "The Endoplasmic Reticulum Retention Signal of the E3/19K Protein of Adenovirus Type 2 Consists of Three Separate Amino Acid Segments at the Carboxy Terminus", J. Cell Biol. 1990, 111, 1803-1810.
Hunter, T. et al., "Protein Kinase C Phosphorylation of the EGF Receptor at a Thronine Residue Close to the Cytoplasmic Face of the Plasma Membrane", Nature 1984, 311, 480-483.
Jackson et al., "Identification of a Consensus Motif for Retention of Transmembrane Proteins in the Endoplasmic Reticulum", The EMBO J. 1990, 9, 3153-3162.
Kozak, M., "Possible Role of Flanking Nucleotides in Recognition of the AUG Initiator Codon by Eukaryotic Ribosomes", Nucleic Acid Res. 1981, 9, 5233-5252.
Krebs, E. and Beavo, "Phosphorylation-Dephosphorylation of Enzymes", Annu. Rev. Biochem. 1979, 48, 923-959.
Lindberg, R. and Hunter, "cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases", Mol. and Cell. Biol. 1990, 10(11), 6316-6324.
Lindberg, R. et al., "Dual-Specificity Protein Kinases: Will Any Hydroxyl Do?" Trends Biochem. Sci. 1992, 17, 114-119.
Morrison, D. et al., "Direct Activation of the Serine/Threonine Kinase Activity of Raf-1 through Tyrosine Phosphorylation by the PDGF .beta.-Rceptor", Cell 1989, 58, 649-657.
Pelham, H.R.B., "Control of Protein Exit from the Endoplasmic Reticulum", Annu. Rev. Cell Biol. 1989, 5, 1-23.
Pleasure, S. et al., "Pure Posmitiotic, Polarized Human Neurons Derived from NTera 2 Cells Provide a System for Expressing Exogenous Proteins in Terminally Differentiated Neurons", J. Neuroscience 1992, 12, 1802-1814.
Rossomando, A. et al., "Evidence that pp42, a Major Tyrosine kinase Target Protein, is a Mitogen-Activated Serine/Threonine Protein Kinase", PNAS USA 1989, 86, 6940-6943.
Taylor et al, "Structural Framework for the Protein Kinase Family", Annu. Rev. Cell Biol. 1992, 8, 429-462.
Wernet, W. et al., "The cDNA of the Two Isoforms of Bovine cGMP-Dependent Protein Kinase", FEBS 1989, 251, 191-196.
Wickens, M. and Stephenson, "Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3' End Formation", Science 1984, 226, 1045-1051.
Yarden, Y., "Growth Factor Receptor Tyrosine Kinases", Ann. Rev. Biochem. 1988, 57, 443-78.
Younkin, D. et al., "Inducible Expression of Neuronal Glutamate Receptor Channels in the NT2 Human Cell Line", PNAS USA 1993, 90, 2174-2178.
Pleasure David
Reddy Usharani
Children's Hospital of Philadelphia
Hendricks Keith D.
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