Human leptin receptor-related protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4351723, 4353201, 435325, 536 235, C12N 1512, C12N 1585

Patent

active

057891982

ABSTRACT:
The present invention provides a polynucleotide which identifies and encodes a novel human leptin receptor-related protein (LRRP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding LRRP.

REFERENCES:
Hillier L, et al. "yh73d04.rl Homo sapiens cDNA clone 135367 5 prime." ETS Database Accession No. R32609, Apr. 28, 1995.
Hillier L, et al. "za11a11.s1 Homo sapiens cDNA clone 292220 3 prime." ETS Database Accession No. N62459, Mar. 1, 1996.
Thompson DB, et al. "Human leptin receptor (LEPR) gene, exon 2." Genbank Database Accession No. U59247, May 24, 1996.
Stratagene Catalog, p. 172, 1995.
Sambrook J, et al. "Molecular Cloning: A Laboratory Manual." Cold Spring Harbor Laboratory Press, NY, pp. 8.46-8.52, 1989.
Darnell J, et al. "Molecular Cell Biology." Scientific American Books, Inc., NY, p. 255, 1986.
Chehab, F.F., et al., "Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin" Nature Genetics, 12:318-320 (1996).
Chen, H., et al., "Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice"Cell, 84:491-495 (1996).
Cioffi, J.A., et al., "Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction" Nature Medicine, 2:585-589 (1996).
Huang, M., et al., "Analysis of a 42.5 kb DNA Sequence of Chromosome X Reveals Three tRNA Genes and 14 New Open Reading Frames Including a Gene Most Probably Belonging to the Family of Ubiquitin-Protein Ligases" Yeast, 11:775-781 (1995).
Khachigian, L.M., et al., "Platelet-Derived Growth Factor and Alternative Splicing: A Review" Pathology, 24:280-290 (1992).
Lee, G.H., et al., "Abnormal splicing of the leptin receptor in diabetic mice" Nature, 379:632-635 (1996).
Phillips, M.S., et al., "Leptin receptor missense mutation in the fatty Zucker rat" Nat. Genet., 13:18-19 (1996).
Tartaglia, L.A., et al., "Identification and Expression Cloning of a Leptin Receptor, OB-R" Cell, 83:1263-1271 (1995).
Thomas, P.M., et al., "Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy" Science, 268:426-429 (1995).
Wilson, R., et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans" Nature, 368:32-38 (1994).
Zhang, Y., et al., "Positional cloning of the mouse obese gene and its human homologue" Nature, 372:425-432 (1994).
Marra, M. et al. (GI 1368126), GenBank Sequence Database (Accession W62925), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Hillier, et al. (GI 1232038), GenBank Sequence Database (Accession N74753), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Pelleymounter, M.A. et al., "Effects of the obese Gene Product on Body Weight Reduction in ob/ob Mice" Science (1995) 269:541-543.
Bailleaul, B. et al., "The leptin receptor promoter controls expression of a second distinct protein" Nuc.Acids Res. (1997) 25:2752-2758.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human leptin receptor-related protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human leptin receptor-related protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human leptin receptor-related protein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1175848

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.