Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-11-04
1997-05-13
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4351723, 4352543, 4352523, 43525411, 4353201, 4352542, 43525421, 435325, 435365, 435358, 514 12, 530300, 530324, 530356, 536 235, 930250, C12P 2106, C12N 120, A61K 3800, C07K 100
Patent
active
056291760
ABSTRACT:
A variant of the C-terminal Kunitz-type protease inhibitor domain of the .alpha.3 chain of human type VI collagen, the variant comprising the following amino acid sequence X.sup.1 X.sup.16 Asp Ile Cys Lys Leu Pro Lys Asp X.sup.2 Gly X.sup.3 Cys X.sup.4 X.sup.5 X.sup.6 X.sup.7 X.sup.8 X.sup.9 Trp Tyr Tyr Asp Pro Asn Thr Lys Ser Cys Ala Arg Phe X.sup.10 Tyr Gly Gly Cys X.sup.11 X.sup.12 X.sup.13 Glu Asn Lys Phe X.sup.14 Ser Gln Lys Glu Cys Glu Lys Val Cys Ala Pro X.sup.15 (SEQ ID NO. 1) wherein X.sup.1, X.sup.15, and X.sup.16 represents a naturally occurring amino acid residues except Cys and X.sup.2 -X.sup.14 each independently respresents a naturally occurring amino acid residue, with the proviso that at least one of the amino acid residues X.sup.1 -X.sup.16 is different from the corresponding amino acid residue of the native sequence. Alternatively, the N-terminal Asp may be preceded by H or 3-5 amino acid residues and the C-terminal Pro may be followed by OH or 3-5 amino acid residues.
REFERENCES:
patent: 5278285 (1994-01-01), Ebbers et al.
Chemical Abstracts No. 147399x, vol. 113, No. 17 (Oct. 22, 1990), p. 289.
Larvin et al "Intra-Peritoneal Aprotinin Therapy for Acute Paucueatitis", Bio. Chem. Hoppe Seyer 369 (Suppl): 149-152 (May 1988).
Brinkmann et al, "Recombinant aprotinin . . . " Eur. J. Biochem 202:95-99 (1991).
Schulz et al, "Principles of Protein Structure", pp. 14-16 (1979).
Bonaldo et al, "The Carboxyl Terminus of the Chicken .alpha. 3 chain of Collagen VI . . . ", J. Biol. Chem. 264(34):20235-20239, (Dec. 1989).
Chu et al, "Mosaic Structure of . . . human type VI collagen .alpha. 3 chainin" The EMBO J 9(2):385-393 (1990).
Broze et al, "Regulation of Coagulation . . . " Biochem 29(33):7539-7546 (Aug. 1990).
Bj.o slashed.rn S.o slashed.ren E.
Norris Fanny
Norris Kjeld
Olsen Ole H.
Petersen Lars C.
Agris, Esq. Cheryl H.
Kim Hyosuk
Novo Nordisk A S
Wax Robert A.
Zelson Esq. Steve T.
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