Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-12
1996-11-19
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 691, 435189, 4352402, 4353201, 514 2, 530350, 536 221, 536 231, 536 232, 536 235, A61K 3800, C12P 2106, C07K 100, C07H 1900
Patent
active
055762948
ABSTRACT:
Variant of human Kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI), the variant comprising the following amino acid sequence ##STR1## wherein Xaa at position 1 is H or a naturally occurring amino acid residue except Cys, each Xaa at positions 2-5 is independently a naturally occurring amino acid residue except Cys or is absent, each Xaa at positions 14, 16, 18, 19, 20, 21, 22, 23, 37, 42, 43, 44, and 49 independently a naturally occurring amino acid except Cys, each Xaa at positions 61, 62, 63, and 64 is independently a naturally occurring amino acid except Cys or is absent, and Xaa at position 65 is OH or a naturally occurring amino acid except Cys, with the proviso that at least one of the amino acid residues designated Xaa is different from the amino acid residue of the native sequence.
REFERENCES:
patent: 5106833 (1993-04-01), Broze, Jr. et al.
Girard et al., "Functional significance . . . ", Nature, vol. 338, pp. 518-520, Apr. 6, 1989.
Glover, "Recombination and mutagenesis", Gene Cloning, pp. 21-45, 1984.
Bj.o slashed.rn S.o slashed.ren E.
Norris Fanny
Norris Kjeld
Olsen Ole H.
Petersen Lars C.
Kim Hyosuk
Lambiris Elias J.
Novo Nordisk A S
Wax Robert A.
Zelson Steve T.
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