Human kininogen D3 domain polypeptide as an anti-angiogenic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S001690, C530S380000

Reexamination Certificate

active

07119069

ABSTRACT:
Human kininogen domain 3 (HK-D3) polypeptides and biologically active variants and derivatives of HK-D3 are anti-angiogenic. These molecules are used to inhibit angiogenesis or treat a disease or condition in which angiogenesis is pathogenic. Because of their anti-angiogenic potential, these molecules compounds are useful in the treatment of cancer by inhibiting or reversing the growth of primary or metastatic tumors.

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patent: 6348185 (2002-02-01), Piwnica-Worms
patent: 6869931 (2005-03-01), McCrae
patent: 2002/0082517 (2004-04-01), Dewitt et al.
patent: WO 00/27866 (2000-05-01), None
patent: WO 00/35407 (2000-06-01), None
Isordia-Salas, I. et al. Blood 102(8): 2835-2842 (2003).
Zhang et al. Can J. Physiol. Pharmacol. 80 85-90 (2002).

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