Human kininogen D3 domain polypeptide as an anti-angiogenic...

Details Human kininogen D3 domain polypeptide as an anti-angiogenic... Human kininogen D3 domain polypeptide as an anti-angiogenic...

2006-08-29

2006-08-29

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C530S350000

Reexamination Certificate

active

07098187

ABSTRACT:
Human kininogen domain 3 (HK-D3) polypeptides and biologically active variants and derivatives of HK-D3 are anti-angiogenic. These molecules are used to inhibit angiogenesis or treat a disease or condition in which angiogenesis is pathogenic. Because of their anti-angiogenic potential, these molecules are useful in the treatment of cancer by inhibiting or reversing the growth of primary or metastatic tumors.

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patent: WO 00/27866 (2000-05-01), None
patent: WO 00/35407 (2000-06-01), None
Zhang et al. Can. J. Physiol. Pharmacol. 80: 85-90 (2002).
WO 00/35407.
Isordia-Salas, I. et al. Blood 102(8): 2835-2842 (2003).

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