Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-08-19
2000-08-01
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 231, C12P 2106, C12N 120, C12N 1500, C07H 2102
Patent
active
060965177
ABSTRACT:
HNBC1A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNBC1A polypeptides and polynucleotides in the design of protocols for the treatment of ischemia heart disease, arrhythmia, congestive heart disease, stroke and renal failure, among others, and diagnostic assays for such conditions.
REFERENCES:
Choi et al. Sodium bicarbonate cotransporter (hhNBC) cloned from human heart cDNA library. Sequence submission: Cellular and molecular Physiology, Yale University, New Haven, CT. Acc. No. AF069510, Jun. 1998.
Burnham et al. "Cloning and Functional Expression of a Human Kidney Na.sup.+ : HCO.sup.- .sub.3 Cotransporter", Journal of Biological Chemistry, vol. 272(31), pp. 19111-19114 (1997).
Romero et al. "Expression cloning and characterization of a renal electrogenic Na.sup.+ /HCO.sup.- .sub.3 cotransporter", Nature, vol. 387, pp. 409-413 (1997).
GenBank Accession #AF007216.
GenBank Accession #AF001958.
Boron Walter F
Bril Antoine Michel Alain
Khandoudi Nassirah
Martin Xavier
Carlson Karen Cochrane
Han William T.
King William T.
Pharmaceutiques and Yale University School of Medicine
Schnizer Holly
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