Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2005-05-17
2005-05-17
Kemmerer, Elizabeth (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S069100, C435S006120, C435S320100, C435S325000, C435S254110, C530S350000, C536S023500
Reexamination Certificate
active
06893858
ABSTRACT:
An isolated polynucleotide encoding a novel potassium channel polypeptide, KCNQ5, that is expressed primarily in brain and skeletal muscle is described. The new polypeptide has been cloned and isolated from a human brain cDNA library and is a member the KCNQ family of potassium channels. The provided human KCNQ5 nucleic acid sequence and encoded polypeptide can be employed for diagnostic, screening and therapeutic uses. Moreover, the hKCNQ5 polypeptide can be used to assay for KCNQ5 potassium channel modulators, which can be utilized in the treatment of neurological, neurophysiological, neuropsychological and neuroaffective diseases, conditions and disorders, including, but not limited to, acute and chronic pain, migraine, acute stroke, dementia, vascular dementia, trauma, epilepsy, amyelotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson's Disease, learning and cognitive disorders, and neurophysiological disorders including anxiety disorders, depression, bipolar disorders, sleep disorders, addiction, and eating disorders.
REFERENCES:
patent: 20020102677 (2002-08-01), Jegla
patent: Wo 9907832 (1999-02-01), None
patent: WO 0061606 (2000-10-01), None
patent: WO 0077035 (2000-12-01), None
patent: WO 0170811 (2001-09-01), None
Voet et al. Biochemistry. 1990. John Wiley & Sons, pp. 126-128 and 228-234.*
Eck & Wilson in Goodman & Gilman's The Pharmacological Basis of Therapeutics. Ninth Edition. McGraw Hill, New York, 199 pages 77-101.*
A.D. Wickenden et al., 2001, Br. J. Pharmacol., 132(2):381-384.
C. Kananura et al., 2000, Neuroreport., 11(9):2063-7.
B.C. Schroeder et al., 2000, J. Biol. Chem., 4:275(31):24089-24095.
C. Lerche et al., 2000, J. Biol. Chem., 275(29):22395-22400.
NCBI Accession No. AF249278,Homo sapiensvoltage-gated potassium channel (KCNQ5) mRNA, complete cds; Submitted: Mar. 24, 2000; Released: Aug. 2, 2000; Ref.: Lerche et al., 2000, J. Biol. Chem., 275(29):22395-22400.
NCBI Accession No. AF202977,Homo sapiensvoltage-gated channel, KQT-like Subfamily, member 5 (KCNQ5) mRNA, Submitted: Nov. 9, 1999; Released Aug. 1, 2000; Ref.: Schroeder et al., 2000, J. Biol. Chem., 275(31):24089-24095.
NCBI Accession No. AF263836, Mus musculus voltage-gated potassium channel KCNQ5 (Kcnq5) mRNA, partial cds., Submitted: May 4, 2000; Released: Jun. 1, 2000; Ref.: M. Kniazeva et al., unpublished.
Database EBI “On line”, Hinxton, UK. Accession No. AF202977, May 14, 2000.
Database EBI ‘Online’ Hinxton, UK; AW049888, Mar. 4, 2000, XP002173772, nucleotides 1-584.
Pongs, O. FEBS Letters, vol. 452, pp. 31-35 (1999).
Dworetzky Steven I.
Gribkoff Valentin K.
Ramanathan Chandra S.
Trojnacki Joanne T.
Bristol--Myers Squibb Company
Buchholz Briana
Kemmerer Elizabeth
Lamerdin John A.
Murphy Joseph F.
LandOfFree
Human kcnq5 potassium channel, methods and compositions thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human kcnq5 potassium channel, methods and compositions thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human kcnq5 potassium channel, methods and compositions thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3416457