Human K + channel polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Details

C530S300000, C424S184100, C424S185100, C424S192100, C435S069100

Reexamination Certificate

active

10188297

ABSTRACT:
The present invention relates to a novel human K+ion channel, to nucleic acid molecules encoding the same and to vectors comprising said nucleic acid molecules. The invention additionally relates to antibodies specifically directed to the novel K+ion channel and to pharmaceutical compositions and diagnostic kits containing at least one of the above-mentioned components. Furthermore, the present invention relates to methods of treating a disease caused by malfunction of the polypeptide of the present invention or by the (over)expression of the nucleic acid molecule of the invention comprising administering an inhibitor of said (over)expression or of ion channel function or an inhibitor abolishing said malfunction to a patient in need thereof. Methods of devising drugs for treating or preventing the above-mentioned disease, methods of inhibiting cell proliferation and methods of prognosing cancer are additional embodiments comprised by the present invention. The invention also envisages specific antisense or gene therapies on the basis of the nucleic acid molecule of the invention for inhibiting undesired cellular proliferation, for example, in connection with cancer or in neurodegenerative diseases.

REFERENCES:
patent: WO92/11034 (1992-07-01), None
patent: WO94/18961 (1994-09-01), None
J. Ludwig, et al., “Functional expression of a rat homologue of the voltage gatedether a go-gopotassium channel reveals differences in selectivity and activation kinetics between theDrosophilachannel and its mammalian counterpart,”The EMBO Journal, 13(19), pp. 4451-4458 (1994).
T. Occhiodoro, et al., “Cloning of a humanether-a-go-gopotassium channel expressed in myoblasts at the onset of fusion,”FEBS Letters434, pp. 177-182 (1998).
H. Suessbrich, et al., “Blockade of HERG channels expressed inXenopusoocytes by the histamine receptor antagonists terfenadine and astemizole,”FEBS Letters, 385, pp. 77-80 (1996).
M.C. Trudeau, et al., “HERG, a human inward rectifier in the voltage-gated potassium channel family,”Science, 269, pp. 92-95 (1995).
J.W. Warmke, et al., “A family of potassium channel genes related toeaginDrosophilaand mammals,”Proc. Natl. Acad. Sci. USA, 91, pp. 3438-3442 (1994).
Finch et al., “Altered Expression of Keratinocyte Growth Factor and Its Receptor in Psoriasis,”American Journal of Pathology, 151(6): 1619-1628 (1997).

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