Human Jak2 kinase

Details Human Jak2 kinase Human Jak2 kinase

1995-12-05

1999-06-22

Sisson, Bradley L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 530324, 530350, 935 1, 935 9, 935 11, C07H 2104, C12N 1500

Patent

active

059143932

ABSTRACT:
The present invention provides a polynucleotide (hjak2) which identifies and encodes a novel human Jak2 kinase (HJAK2) which was expressed in the placenta. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified HJAK2 peptide, antibodies capable of binding to HJAK2, inhibitors which bind to HJAK2 and pharmaceutical compositions based on HJAK2 specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered hjak2 expression and which allow identification of such a condition. These assays utilize probes which comprise oligomers, fragments, or portions of hjak2 or its regulatory elements or antibodies specifically binding HJAK2.

REFERENCES:
Taniguchi, T., "Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases," Science , 268:251-255 (1995).
David, M. et al., "Requirement for MAP Kinase (ERK2) Activity in Interferon .alpha.-and Interferon .beta.-Stimulated Gene Expression Through STAT Proteins," Science, 269:1721-1723 (1995).
Herrera-Gonzalez and Dresser, "Fetal-Maternal Immune Interaction: Blocking Antibody and Survival of Fetus," Dev. Comp. Immunol., 17(1) :1-18 (1993).
Mitchell et al., "Cytokine Networking in the Placenta," Placenta, 14:249-275 (1993).
Rutanen, "Cytokines in Reproduction," Ann. Med. 25:343-347 (1993).
Strosberg, A.D. et al., "Functional Expression of Receptors in Microorganisms", Trends in Pharmacological Sciences, 13(3) :95-98, 1992.
Grynkiewicz, G. et al., "A New Generation of Ca.sup.2+ Indicators with Greatly Improved Fluorescence Properties," The Journal of Biological Chemistry, 260(3) :3440-3450, 1985.
McColl, S. et al., "Uncoupling of Early Signal Transduction Events from Effector Function in Human Peripheral Blood Neutrophils in Response to Recombinant Macrophage Inflammatory Proteins-1.alpha. and -1.beta.," The Journal of Immunology, 150:4550-4560 (1993).
Wilks, A. F., "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction," Proc. Nalt. Acad. Sci. USA, PNAS 86:1603-7 (1989).
Silvennoinen et al., "Structure of the murine Jak2 protein-tyrosine kinase and its role in interlukin 3 signal transduction," Proceedings of the NationalAcademy of Sciences, USA, vol. 90, pp. 8429-8433, Sep. 1993.
Nierman et al., eds., ATCC/NIH Repository Catalog of Human and Mouse DNA Probes and Libraries, Eighth Edition, pp. 1-70, 1994.

Affiliated with

Also associated with

Rating

Human Jak2 kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human Jak2 kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human Jak2 kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1708746