Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-09-20
1998-11-17
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241851, 435 693, 530300, 530395, 536 235, 536 2351, C07K 14435, A61K 3900
Patent
active
058378120
ABSTRACT:
The present invention relates to the identification, cloning and sequencing of nucleic acid molecules encoding an isoform of the enzyme glutamic acid decarboxylase and further relates to the use of these molecules and/or peptides and polypeptides encoded thereby in diagnostic tests for Insulin Dependent Diabetes Mellitus and other diseases in which glutamic acid decarboxylase is an autoantigen and in the treatment of patients suffering from these diseases.
REFERENCES:
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Baekkeskov, et al. (Sep. 13, 1990) "Identification of the 64K Autoantigen in Insulin-Dependent Diabetes as the GABA-Synthesizing Enzyme Glutamic Acid Decarboxylase", Nature 347:151-156.
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Cram David
De Aizpurua Henry
Harrison Leonard
Honeyman Margot
Amrad Corporation Limited
Cunningham Thomas M.
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