Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-02-27
2000-10-10
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 536 231, 536 243, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2104
Patent
active
061300411
ABSTRACT:
The present invention is based at least in part on the discovery of the genomic structure of the human SR-BI gene and on the identification of polymorphic regions within the gene. Accordingly, the invention provides nucleic acids having a nucleotide sequence of an allelic variant of an SR-BI gene and nucleic acids having an SR-BI intronic sequence. The invention also provides methods for identifying specific alleles of polymorphic regions of an SR-BI gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an SR-BI gene, and kits for performing such methods.
REFERENCES:
Cao et al., J. Biol. Chem. 272(52), 33068-33076 (Dec. 1997).
Acton, S.L. et al. "Expression Cloning of SR-BI, a CD36-related Class B Scavenger Receptor" J. Biol. Chem. 269 (33):21003-21009, 1994.
Acton, S. et al. "Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor" Science 271:518-520, 1996.
Calvo, D. and Vega, M.A. "Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPH gene family" J. Biol. Chem. 268 (25):18929-18935, 1993.
Calvo, D. et al. "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) Gene Family: Cellular Distribution, Chromosomal Location, and Genetic Evolution" Genomics 25:100-106, 1995.
Fukasawa, M. et al. "SRB1, a Class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells" Exper. Cell Research 222:246-250, 1996.
Landschulz, K. et al. "Regulation of Scavenger Receptor, Class B, Type 1, a High Density Lipoprotein Receptor in Liver and Steroidogenic Tissues of the Rat" The American Cancer Society for Clinical Investigation, Inc. vol. 98, No. 4, Aug. 1996 pp. 984-995.
Riggotti,, A. et al. "The Class B Scavenger SR-BI and CD36 are Receptors for Anionic Phospholipids" J. Biol. Chem. 270(27):16221-16224, 1995.
Riggoti, A. et al. "Regulation by Adrenocorticotropic Hormone of the in Vivo Expression of Scavenger Receptor Class B Type I (SR-BI), a High Density Lipoprotein Receptor, in Steroidogenic Cells of the Murine Adrenal Gland" The Journal of Biological Chemistry, vol. 271, No. 52 Dec. 27, pp. 33545-33549, 1996.
Tang, Y. et al. "Identification of a Human CD36 Isoform Produced by Exon Skipping" J. Biol. Chem 269(8):6011-6015, 1994.
Wang, N. et al. "Scavenger Receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores" J. Biol. Chem 271 (35):21001-21004, 1996.
Hillier, L. et al. "The WashU-Merck EST project (AC H22816)" EMEST13, 1995 XP002095407, Heidelberg.
Hillier, L. et al. "The WashU-Merck EST project (AC T39475)" EMEST13, 1995, XP002095408, Heidelberg.
Hillier, L. et al. "The WashU-Merck EST project (AC R59536)" EMEST13, 1995, XP002095409, Heidelberg.
Sanger, F. et al. "DNA Sequencing with Chain-Terminating Inhibitors" PNAS, 74(12): 5463-5467, Dec. 1977, XP000604551.
Botstein, D. et al. "Construction of a Genetic Linkage Map in Man Using Restriction Fragment Length Polymorphisms" Am. J. Hum. Gen. 32(3):314-331, May 1980, XP000610566.
Orita, M. et al. "Detection of Polymorphisms of Human DNA by Gel Electrophoresis as Single-Strand Conformation Polymorphisms" PNAS 86(8):2766-2770, Apr. 1989, XP000310584.
Saiki, R.K. et al. "Genetic Analysis of Amplified DNA with Immobilized Sequence-Specific Oligonucleotide Probes" PNAS 86(16):6230-5234, Aug. 1989, XP000268602.
Nickerson, D. et al. "Automated DNA Diagnostic Using an ELISA-Based Ologonucleotide Ligation Assay" PNAS 87(22):8923-8927, Nov. 1990, XP000209335.
Ganguly, A. et al. "Detection of Single-Based Mutations by Reaction of DNA Heteroduplexes with a Water-Soluble Carbodiimide Followed by Primer Extension: Application to Products from the Polymerase Chain Reaction" Nuc. Acids Res. 18(13):3933-3939, 1990, XP002033171.
International Search Report for PCT/US98/14359, dated Mar. 16, 1999.
Frossard, P.M. et al. "Apal RFLP 5.4 kn 5' to the human apolipoprotein AI (APO A1) gene" Nuc. Acids Res. 14(4), 1986, XP002090828.
Varban, M.L. et al. "Targeted mutation reveals a central role for SR-B1 on hepatic selective uptake of high density lipoprotein cholesterol" PNAS 95:4619-4626, Apr. 1998, XP002090830.
Rigotti, A. et al. "Targeted mutation of the gene encoding SR-B1 establishes that it plays a key role in HDL metabolism" FASEB Journal 11(9):A1292, 1997, XP002090831.
Horlick Kenneth R.
Millennium Pharmaceuticals Inc.
LandOfFree
Human intronic and polymorphic SR-BI nucleic acids and uses ther does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human intronic and polymorphic SR-BI nucleic acids and uses ther, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human intronic and polymorphic SR-BI nucleic acids and uses ther will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2255170