Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Tissue – other than lymphoid tissue
Patent
1994-08-10
1996-06-18
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Tissue, other than lymphoid tissue
A61K 3512
Patent
active
055275460
ABSTRACT:
A previously undescribed Interleukin-6 inhibitor activity has been successfully isolated from the supernatant of the human promyelocytic leukemia cell line HL-60. Treatment of the HL-60 cell line with cycloheximide prevents the appearance of the inhibitory activity in the cellular supernatant. Incubation of the HL-60 supernatant with trypsin destroys the activity. The above observations indicate the inhibitor is a protein. Membrane and gel filtration studies indicate the protein has a molecular weight between 10,000 and 30,000 daltons. The inhibitor was partially isolated from other proteins by dye-ligand and reverse phase chromatography.
REFERENCES:
Twigg et al., J. Lab Clin Med. 124(2):283-292 (1994).
Faris Susan K.
Lembach Kenneth J.
Penza Delia E.
Bayer Corporation
Giblin James A.
Wityshyn Michael G.
Witz Jean C.
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