Human interferon-gamma

Details Human interferon-gamma Human interferon-gamma

1988-01-19

1990-11-13

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351723, 435 6951, 4353171, 435320, 935 22, 935 23, 935 34, C12N 1500, C12N 500, C12P 2100

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active

049701614

ABSTRACT:
A DNA sequence on which a chromosomal DNA sequence coding for human interferon-.gamma. (HuIFN-.gamma.) and having a TATA box is ligated to a sequence of a promoter. Cell cultures transformed with said DNA revealed a higher expression of HuIFN- than cell cultures transformed with a DNA which does not have such TATA box. When transformed with said DNA, cell cultures produced HuIFN-.gamma. in a serum free medium. Transformed cell cultures derived from blood cells of HuIFN-.gamma. resistant human cell-line also could produce HuIFN-.gamma..

REFERENCES:
Lewin, Genes, John Wiley & Sons Pub., pp. 186-192, (1983).
Phil. Trans. R. Soc. Land. B 299, 29 (1982), Fiers et al.
Proc. Natl. Acad. Sci. USA, vol. 81, pp. 5086-5090, Aug. 1984, Fukunaga et al.
Proc. Natl. Acad. Sci. USA, vol. 79, pp. 7857-7861, Dec. 1982, Le et al.
Genetic Engineering, vol. 2, Sellow et al. ed. Plenum, New York, 83-101, (1980), Hamer.
The EMBO Journal, vol. No. 8, pp. 953-958, 1982, Taya et al., European Search Report.

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