Human insulin analogues

Details Human insulin analogues Human insulin analogues

1989-12-20

1992-11-17

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530303, 435 694, C07K 740, A61K 3726

Patent

active

051643669

ABSTRACT:
The present invention relates to novel human insulin analogues exhibiting a low ability to associate in solution, a method for the preparation of such insulin analogues, insulin preparations containing the human insulin analogues of the invention and a method of treating Diabetes Mellitus using these human insulin analogues.

REFERENCES:
patent: 3903069 (1975-09-01), Geregory
patent: 4320196 (1982-03-01), Morihara et al.
patent: 4701440 (1987-10-01), Grau
Frank, B., "Self-Assocation and Confermational Studies on Human Poinsulin and Insulin Analogs", Abstract, Conference on Insulin, 1989.
Chance, R., "Preparation of a New Series of Insulin Analogs", Conference on Insulin, Sep. 1989.
Nakagawa, S. et al., Journal of Biological Chemistry, 262(25): 12054-58, Sep. 1987.

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