Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1999-05-19
2000-10-10
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 21, 435196, 4352523, 4353201, 536 232, 536 235, 530350, 4241301, 4241421, 4241461, G01N 168, C12Q 142, C12N 916, C07N 2104, C07K 1400
Patent
active
061300519
ABSTRACT:
Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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Bone, R., et al., Proc. Natl Acad. Sci., vol. 89:10031-10035 (1992).
Gocayne Jeannine D.
Meissner Paul S.
Achutamurthy Ponnathapu
Human Genome Sciences Inc.
Saidha Tekchand
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