Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-02-09
1999-09-21
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435 691, 4352523, 4353201, 536 232, 536 235, 530350, C12N 916, C12N 120, C12N 1500, C12P 2106
Patent
active
059553391
ABSTRACT:
Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed is antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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McAllister, G. et al., Biochemical Journal, 284:749-754 (1992).
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Wreggett, K., Biochemical Journal, 286:147-152 (1992).
Gocayne Jeannine D.
Meissner Paul S.
Brookes A. Anders
Human Genome Sciences Inc.
Saidha Tekchand
Wax Robert A.
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