Human inhibin

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530324, C07K 710, C07K 1300

Patent

active

047375787

ABSTRACT:
Proteins with inhibin activity having a weight of about 32,000 daltons. The molecule is composed of two chains having molecular weights of about 18,000 and about 14,000 daltons, respectively, which are bound together by disulfide bonding. The 18K chain is obtained from the human inhibin gene and has the formula: H-Ser-Thr-Pro-Leu-Met-Ser-Trp-Pro-Trp-Ser-Pro-Ser-Ala-Leu-Arg-Leu-Leu-Gln- Arg-Pro-Pro-Glu-Glu-Pro-Ala-Ala-His-Ala-Asn-Cys-His-Arg-Val-Ala-Leu-Asn-Ile -Ser-Phe-Gln-Glu-Leu-Gly-Trp-Glu-Arg-Trp-Ile-Val-Tyr-Pro-Pro-Ser-Phe-R.sub. 65 -Phe-His-Tyr-Cys-His-Gly-Gly-Cys-Gly-Leu-His-Ile-Pro-Pro-Asn-Leu-Ser-Leu-P ro-Val-Pro-Gly-Ala-Pro-Pro-Thr-Pro-Ala-Gln-Pro-Tyr-Ser-Leu-Leu-Pro-Gly-Ala- Gln-Pro-Cys-Cys-Ala-Ala-Leu-Pro-Gly-Thr-Met-Arg-Pro-Leu-His-Val-Arg-Thr-Thr -Ser-Asp-Gly-Gly-Tyr-Ser-P e-Lys-Tyr-Glu-Thr-Val-Pro-Asn-Leu-Leu-Thr-Gln-His-Cys-Ala-Cys-Ile-OH, wherein R.sub.65 is Ile or Arg. The 18K chain is connected by disulfide bonding to the 14K chain.

REFERENCES:
Chem. Abstr., vol. 94 (1981), 187299.
Chem. Abstr., vol. 92 (1980), 2711.
Chem. Abstr., vol. 92 (1980), 106678.
Chem. Abstr., vol. 90 (1979), 99634.
Chem. Abstr., vol. 105 (1986), 127623.
Chem. Abstr., vol. 103 (1985), 65677.
Chem. Abstr., vol. 103 (1985), 98880.
Chem. Abstr., vol. 103 (1985), 172217.
Chem. Abstr., vol. 98 (1983), 28231.
A. J. Mason et al., "Complementary DNA Sequences of Ovarian Follicular Fluid Inhibin Show Precursor Structure and Homology with Transforming Growth Factor-B", Biochem. Biophys. Res. Commun., 135, 957-964 (1986).
A. J. Mason et al., "Structure of Two Human Ovarian Inhibins", Nature, 318, 659-663 (1985).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human inhibin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human inhibin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human inhibin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1430058

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.