Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Reexamination Certificate
2006-02-14
2006-02-14
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
C424S009100, C424S009200, C435S325000, C435S366000, C435S371000, C435S383000, C800S008000, C800S009000
Reexamination Certificate
active
06998513
ABSTRACT:
The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental models of inflammatory carcinoma in order to dissect out the molecular basis of this phenotype. This experimental model of inflammatory carcinoma can be used to identify molecular targets for therapeutic intervention and to assess the efficacy of a broad spectrum of diagnostic and therapeutic agents. Specific animal models of inflammatory breast cancer are described as well as methods for evaluating diagnostic and therapeutic agents for treating inflammatory breast cancer. Methods for identifying molecules whose expression is modulated in inflammatory breast cancer are provided. In addition, methods for diagnosing and inhibiting the growth of inflammatory breast cancer metastases in vivo are provided.
REFERENCES:
patent: 5508188 (1996-04-01), Barsky et al.
Saadi et al.; MiniReview Immunology of Xenotransplantation; Life Sciences, vol. 62, No. 5, pp 365-387, 1998.
Gill; Use of Small Animal Models for Screening Immunoisolation Approaches to Cellular Transplantation; Screening Immunoisolation: pp 35-46.
Kleer et al.; Review: Molecular biology of breast cancer metastasis inflammatory breast cancer: clinical syndrome and molecular determinanants; Breast Cancer Res 2000, 2:423-429.
Kleer et al.; Presistent E-Cadherin Expression in Inflammatory Breast Cancer; Mod Pathol 2001; 14(5):458-464.
Gura et al. (1997) Systems for identifying new drugs are often faulty. Science 278: 1041-1042.
Chrysogelos, S.A., “Chromatin Structure of EGRF Gene Suggests a Role for Intron 1 Sequences in its Regulation in Breast Cancer Cells”,Nucleic Acids Research, 1993, vol. 21, No. 24, pp. 5736-5741.
Schiemann, S. et al., “Molecular Analysis of Two Mammary Carcinoma Cell Lines at the Transcriptional Level as a Model System for Progression of Breast Cancer”,Clinical Experimental Metastasis, 1998, vol. 16, pp. 129-139.
Brunner, N. et al., Effect of Endocrine Therapy on Growth of T61 Human Breast Cancer Xenografts is Directly Correlated to a Specific Down-Regulation of Insulin-Like Growth Factor II (IGF-II).European Journal of Cancer, 1993, vol. 29A, No. 4, pp. 562-569.
Guerin, M. et al., “Structure and Expression of c-erb B-2 and EGF Receptor Genes in Inflammatory and Non-Inflammatory Breast Cancer: Prognostic Significance”,International Journal of Cancer, 1989, vol. 43, pp. 200-208.
Shao, M. et al., “A Human Inflammatory Breast Carcinoma Xenograft Model of the Intravasation Step of Metastasis”, FASEB Journal, Mar. 12, 1999, vol. 13, No. 4 Part 1, pp. A187, Abstract No. 174.9.
Chun, M., “Plasmin Induces the Formation of Multicellular Spheroids of Breast Cancer Cells”,Cancer Letters, 1997, vol. 117, pp. 51-56.
Alpaugh Mary L.
Barsky Sanford H.
Tomlinson James S.
Falk Anne-Marie
Gates & Cooper LLP
The Regents of the University of California
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