Human immunoglobulin and enhancer gene fragments

Details Human immunoglobulin and enhancer gene fragments Human immunoglobulin and enhancer gene fragments

1989-03-21

1992-03-31

Doll, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 7021, 4351723, 4353201, 435972, 436512, 424 858, 935 15, 935 3, 935 33, C12N 1513, A61K 3900, C07H 1700

Patent

active

051010240

ABSTRACT:
The present invention provides an enhancer DNA segment, a gene fragment having (a) the enhancer DNA segment and (b) a structural gene such as human D, V and J gene, and a promoter. A hybrid DNA (1) having a phage DNA fragment from Charon 4A phage vector and human DNA fragments, a Charon 4A phage containing the hybrid DNA (1), a hybrid DNA (2) having a PBR322 fragment and human DNA fragment, a transformant of E. coli C600 strain transformed with the hybrid DNA (2), plasmid pSV2-H1G1 obtained by inserting a human DNA fragment into a vector pSV-2gpt, a transformant of E. coli MC 1000 strain transformed with the plasmid pSV2-H1G1 and a transformant of mouse myeloma cells J558L or NS-1 transformed with the plasmid pSV2-H1G1 are also provided.

REFERENCES:
patent: 4663281 (1987-05-01), Gillies et al.
Gillies et al., Cell 33: 717-728, 1983 (Jul.).
Banerji et al. Cell 33: 729-740, 1983 (Jul.).
Maniatis et al, In Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Labs. 1982, pp. 3-5, 24-27 and 31.
Rabbitts et al., Nature 306: , 806-809, 1983 (Dec.).
Hayday et al., Nature 307: 334-340, 1984 (Jan.).
Hieter et al., "Chem. Abst." 94 Col. 81895m (1981).
Siebenlist et al., "Nature", 294 631-635 (1981).
Ellison et al., "Nucleic Acids Research", 10(13), 4071-4079 (1982).

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