Human immunodeficiency virus specific proteolytic enzyme and a m

Details Human immunodeficiency virus specific proteolytic enzyme and a m Human immunodeficiency virus specific proteolytic enzyme and a m

1987-06-01

1993-10-12

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352351, 435236, 5303891, 5303894, 536 232, C12N 950, C12N 704, C12N 1584

Patent

active

052524779

ABSTRACT:
HIV protease necessary for the natural synthesis of HIV has been identified and sequenced. Rabbit antiserum against the C-terminal portion of HIV protease has been produced and used to isolate natural HIV protease and characterize its activity. In addition, a method for producing synthetic HIV protease having the correct stereospecific conformation and specific HIV proteolytic activity has been achieved.

REFERENCES:
Oroszlan, S. et al, "Primary Structure and Processing of gag and env Gene Products of Human T-Cell Leukemia Viruses HTLV-I.sub.CR and HTLV-I.sub.ATK, Current Topics in Microbiology and Immunology", vol. 115, pp. 221-233, 1985.
Copeland, T. D., "A Synthetic Dodecapeptide Substrate for Type C RNA Tumor Virus Associated Proteolytic Enzyme", PEPTIDES: Synthesis-Structure-Function, Pierce Chemical Company, 1981; pp. 497-550.
Yoshinaka et al, "Murine Leukemia Virus Protease Is Encoded By the gag-pol Gene and is Synthesized Through Suppression of an Amber Termination Condon", Proc. Natl. Acad. Sci., USA, vol. 82, pp. 1618-1622, Mar. 1985.
Henderson, et al, "Analysis of Proteins and Peptides Purified From Sucrose Gradient Banded HTLV-III, UCLA Symposia on Molecular and Cellular Biology"; New Series, vol. 71, pp. 135-147, May 1988.
Yoshinaka, Y., et al. (1985) J. Virol. 55(3), 870-873.
Yoshinaka, Y., et al. (1986) J. Virol. 57(3), 826-832.
Ratner, et al. (1985) Nature 313, 277-284.
Debouck C., et al. (1987) Proc. Natl. Acad. Sci., USA 84, 8903-8906.

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