Human immunodeficiency virus specific proteolytic enzyme and a m

Details Human immunodeficiency virus specific proteolytic enzyme and a m Human immunodeficiency virus specific proteolytic enzyme and a m

1993-07-30

1994-10-11

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352351, 435236, C12N 950, C12N 704

Patent

active

053546830

ABSTRACT:
HIV protease necessary for the natural synthesis of HIV has been identified and sequenced. This antibody cross reacts with the protease of HIV-2. In addition, a method for producing synthetic HIV-1 and HIV-2 protease having the correct stereospecific conformation and specific HIV proteolytic activity has been achieved. Assays for the synthetic proteases using synthetic peptide substrates have been developed.

REFERENCES:
patent: 5252477 (1993-10-01), Oroszlan et al.
Pearl, L. H., et al. (1987) Nature 328, 482.
Guyader, M., et al. (1987) Nature 326, 662-669.
Pearl, L. H., et al. (1987) Nature 329, 351-354.

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