Human immune interferon

Details Human immune interferon Human immune interferon

1990-07-31

1992-03-17

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

530351, 530395, 435 6951, A61K 3766, C07K 1526

Patent

active

050967053

ABSTRACT:
Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The human immune (gamma) interferon (IFN-.gamma.), is isolated and characterized in terms of DNA and amino acid sequences, physical attributes and biological activity.

REFERENCES:
patent: 4285929 (1981-08-01), Sugimoto et al.
patent: 4382027 (1983-05-01), Braude
Yip et al., Proc. Natl. Acad. Sci., vol. 78, pp. 1601-1605, 1981.
Nathan et al., Nature, vol. 292, pp. 842-844, 1981.
O'Malley, Methods In Enzmology, vol. 78, pp. 540-545, 1981.
Hsieh et al., J. Biol. Chem., vol. 258, pp. 2548-2554, 1983.
Yamashita et al., Archives of Biochemistry, vol. 225, pp. 993-996, 1983.
Nakamura et al., Virology, vol.95, pp. 8-23, 1979.

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