Human IL-2 receptor .gamma. chain molecule

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4353201, 4352523, 43524026, 536 2352, 536 231, 536 235, 935 6, 935 11, 935 22, 935 23, 935 24, 935 66, 935 70, 935 72, 935 73, C12N 500, C12N 1500, C07H 2104

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active

055102590

ABSTRACT:
The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.
Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.

REFERENCES:
Takeshita et al., Science, vol. 257, pp. 379-382, 17 Jul. 1992.
Lymphokine Research, vol. 9, No. 4, pp. 539-542, 1990, K. Sugamura, et al., "IL-2-Induced Signal Transduction: Involvement of Tyrosine Kinase and IL-2 Receptor .gamma. Chain".
Science, vol. 257, pp. 379-382, Jul. 17, 1992, T. Takeshita, et al., "Cloning of the .gamma. Chain of the Human IL-2 Receptor".
The Journal of Immunology, vol. 148, No. 7, pp. 2154-2158, Apr. 1, 1992, T. Takeshita, et al., "An Associated Molecule, p. 64, with IL-2 Recteptor .beta. Chain. Its Possible Involvement in the Formation of the Functional Intermediate-Affinity IL-2 Receptor Complex".
The Embo Journal, vol. 9, No. 12, pp. 3899-3905, 1990, S. M. Zurawski, et al., "Partial Agonist/Antagonist Mouse Interleukin-2 Proteins Indicate that a Third Component of the Receptor Complex Functions in Signal Transduction".

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