Human IL-1 cDNA sequences encoding biologically-active human IL-

Details Human IL-1 cDNA sequences encoding biologically-active human IL- Human IL-1 cDNA sequences encoding biologically-active human IL-

1990-08-21

1991-12-31

Martinell, James

Chemistry: molecular biology and microbiology

Vector, per se

435 6952, 4351723, 536 27, C12N 1500, C12N 1511

Patent

active

050772198

ABSTRACT:
The subject invention concerns truncated human Il-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.

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