Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1998-12-18
2000-02-29
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
435194, 4352532, 4352542, 4353201, 435455, 435471, 536 231, 536 232, 536 235, C12N 1585, C12N 1554, C12N 1563, C07H 2104
Patent
active
060308346
ABSTRACT:
A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compounds.
REFERENCES:
patent: 5851812 (1998-12-01), Goeddel et al.
Woronicz J.D. et al. "I(kappa) B kinase-(beta): NF-(kappa)B activation and complex formation with I(kappa)B kinase-(alpha) and NIK" Science, vol. 278 Oct. 31, 1997 pp. 866-869.
Mercurio F. et al. "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF -kappaB activation" Science, vol. 278, Oct. 31, 1997 pp. 860-866.
Maniatis T. "Catalysis by a Multiprotein I(KAPPA)B Kinase Complex" Science, vol. 278, Oct. 31, 1997, pp. 818-819.
Nakano H. et al. "Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase / ERK kinase--1" Proceedings of the National Academy of Sciences of the United States of America, vol. 95, No. 7, Mar. 31, 1998 pp. 3537-3542.
Chu Keting
Pot David
Blackburn Robert P.
Chiron Corporation
Epps Janet
Hemmendinger Lisa M.
LeGuyader John L.
LandOfFree
Human IKK-beta DNA constructs and cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human IKK-beta DNA constructs and cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human IKK-beta DNA constructs and cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-682145