Human hybridomas and the production of human monoclonal antibodi

Details Human hybridomas and the production of human monoclonal antibodi Human hybridomas and the production of human monoclonal antibodi

1983-05-17

1986-08-26

Warden, Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4351721, 4351722, 435240, 435948, 530387, 436548, 260112B, 935 96, 935100, C12P 2100, C12N 1500, C12N 500, G01N 3353

Patent

active

046083375

ABSTRACT:
The present invention provides a stable, continuous human myeloma cell line which is capable of hybridization with antibody-producing cells of humans and other animals, the cell line being a mutant of GM 1500 human B cells and being deficient in hypoxanthine phosphoribosyltransferase. The invention also comprises processes for the production of hybrid cells employing the stable, HPRT-deficient human myeloma cell line, and processes for the production of antibodies employing such hybrid cells.

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