Human-human hybrid cell lines that produce antibodies against an

Details Human-human hybrid cell lines that produce antibodies against an Human-human hybrid cell lines that produce antibodies against an

1984-10-15

1988-08-02

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435 70, 4351722, 935100, 530387, 424 85, C12N 500, C07K 1504, A61K 39395

Patent

active

047613777

ABSTRACT:
Human-human hybrid cell lines that synthesize and secrete monoclonal antibodies against antigenic determinants on cancer cells, generated by fusing a human lymphoblastoid B cell line to human lymphocytes, and therapeutic and diagnostic uses of the monoclonal antibodies in both cancer treatment and research is disclosed.

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Glassy, M. C. et al., Proc. Natl. Acad. Sci., USA, 80 (20): 6327-6331 (1983).
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Hagiwara, H., and G. Sato. "Human X Human Hybridoma Producing Monoclonal Antibody against Autologous Cervical Carcinoma." Molecular Biology and Medicine. 1983, 1:245-252.

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