Human hookworm model and method for maintaining human...

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease

Reexamination Certificate

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C424S009200, C800S008000

Reexamination Certificate

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10780809

ABSTRACT:
A method for maintaining a human hookworm strain is provided by infecting a non-human primate with a non-adapted or non-passaged human hookworm and maintaining the non-human primate. Methods of obtaining human hookworm materials and compositions, such as for use as a vaccine, are also provided, along with a model for maintaining and investigating human hookworm.

REFERENCES:
Hotez, P.J., et al., “Experimental Approaches to the Development of a Recombinant Hookworm Vaccine”,Immunological Reviews 1999, vol. 171, pp. 163-172 (1999).
Hotez, P.J., et al., “Vaccines for Hookworm Infection”,Pediatric Infectious Disease Journal, vol. 16, No. 10, pp. 935-940 (1997).
Orihel, T.C., “Necator americanusInfection in Primates”,The Journal of Parasitology, vol. 57, No. 1, pp. 117-121 (1971).
Orihel, T.C., “Primates as Models for Parasitological Research”,Medical Primatology Symp. XXII, pp. 772-782 (1971).
Orihel, T.C., “The Helminth Parasites of Nonhuman Primates and Man”,Laboratory Animal Care, vol. 20, No. 2, pp. 395-401 (1970).

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