Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1999-12-28
2000-12-19
Kunz, Gary L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 435 711, 435 712, 4352523, 4353201, 435325, 435471, 536 235, C07K 100, C07K 1400, C07K 1700, C07H 2104, C12P 2104
Patent
active
061628999
ABSTRACT:
HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
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Chambers Jon
Halsey Wendy S
Muir Alison
Sathe Ganesh Madhusudan
Szekeres Philip
Han William T.
King William T.
Kunz Gary L.
Landsman Robert
SmithKline Beecham Corporation
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