Human herpesvirus type 6 protein p100, the corresponding DNA seq

Details Human herpesvirus type 6 protein p100, the corresponding DNA seq Human herpesvirus type 6 protein p100, the corresponding DNA seq

1995-06-06

1998-10-27

Ketter, James

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

435 5, 435 71, 5303883, 5303894, A61K 39245, C12Q 170, G01N 33569, C07K 1608

Patent

active

058275193

ABSTRACT:
The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the corresponding DNA sequences. They can be used in pharmaceutical or diagnostic compositions, optionally together with other HHV-6 proteins or the corresponding DNA sequences.

REFERENCES:
Littler et al., Indentification, Cloning, and Expression of the Major Capsid Protein Gene of Human Herpesvirus 6, Journal of Virology, vol. 64, No. 2, Feb. 1990, pp. 714-772.
Larcher et al., Serological Crossreaction of Human Herpesvirus 6 with Cytomegalovirus, The Lancet, Oct. 22, 1988, pp. 963-964.
Neipel et al., The Unique Region of the Human Herpesvirus 6 Genome is Essentially Collinear With the U .sub.L , Segment of Human Cytomegalovirus, Journal of General Virology (1991), 72, pp. 2293-3397.
Chang et al., Identification, Characterization, and Sequence Analysis of a cDNA Encoding a Phosphoprotein of Human Herpesvirus 6, Journal of Virology, vol. 65, No. 6, Jun. 1991, pp. 288-2894.
Lawrence et al., Human Herpesvirus 6 Is Closely Related to Human Cytomegalovirus, Journal of Virology, vol. 64, No. 1, Jan. 1990, pp. 287-299.
Josephs et al., Genomic Analysis of the Human B-Lymphotropic Virus (HBLV), Science, vol. 234, (Oct. 31, 1986) pp. 601-603.
Neipel et al., Gene for the Major Antigenic Structural Protein (p100) of Human Herpesvirus 6, The Journal of Virology, vol. 66, No. 6, (Jun. 1992), pp. 3918-3924.
Yamamoto et al., Identification of a Nucleocapsid Protein as a Specific Serological Marker of Human Herpesvirus 6 Infection, Journal of Clinical Microbiology, vol. 28, No. 9, Sep. 1990, pp. 1957-1962.

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