Human hepatoma lines, methods for obtaining same and uses...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Reexamination Certificate

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C435S377000, C435S258200, C435S258300, C435S235100

Reexamination Certificate

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07456018

ABSTRACT:
Human hepatoma cell lines are provided that comprises a set of cells clonally derived from a cancerous human liver cell, in which each cell of the set expresses a receptor having an affinity for binding a virus of theFlaviviridaegenus and a virus of theHepadnaviridaegenus to enable infection by viruses of both genus in native forms, and in which each cell of the set exhibits susceptibility to infection by a hepatotropic parasite of theLeishmaniagenus in a native form. Various compositions and methods relating to diagnostic, therapeutic, and prophylactic embodiments are also provided.

REFERENCES:
patent: 4393133 (1983-07-01), Knowles et al.
patent: 5804441 (1998-09-01), Naganori et al.
patent: 0972828 (2000-01-01), None
patent: 0972828 (2000-01-01), None
patent: WO94/08598 (1994-04-01), None
patent: WO96/30492 (1996-10-01), None
Chiu et al., “The Formation of Bile Canaliculi in Human Hepatoma Cell Lines,” 11(5) Hepataology 834-842 (May 1990).
Encke et al., “Genetic Immunization Generates Cellular and Humoral Immune Responses Against the Nonstructural Proteins of the Hepatitis C Virus in a Murine Model,” J Immunol. 161(9):4917-23, 1998.
Fipaldini et al., “Expression of Hepatitis C Virus cDNA in Human Hepatoma Cell Line Mediated by a Hybrid Baculovirus-HCV vector,” Virology 255, 302-311 (1999).
Houghton et al. “Prospects for a vaccine against the hepatitis C virus,” Nature, vol. 436, Aug. 18, 2005.
Hsieh et al., “Improved Gene Expression by a Modified Bicistrionic Retroviral Vector,” Biochemical and Biophysical Research Communications, vol. 214, No. 3 (1995).
Karnasuta et al., “Complete Development of the liver stage of Plasmodium falciparum in a human hepatoma cell line,” Am J Trop Med Hyg, 53(6): 607-11, (Dec. 1995).
Liu et al. “Expression of precore and core proteins of hepatitis B virus in human hepatoma cell line,” Di Yi Jun Yi Da Xue Xue Bao, 22(2): 174-6 (2002).
Nozaki et al., “Establishment of a human hepatoma cell line, HLE/2E1, Suitable for Detection of P450 2E1-Related Cytotoxicity,” In. Vitro. Cell. Dev. Biol.-Animal 36:566-570, Oct. 2000.
Roberts et al., “Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line Hep G2,” Arch Biochem Biophys. 276(2):442-50 1990.
Rodriquez-Antona et al., “Chrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells,” Xenobiotica 32(6): 505-20 (2002).
Saito et al., “Effect of Dexamethasone, dimehtylsulfoxide and sodium butyrate on a human hepatoma cell line PLC/PRF/5,” Cancer Biochem. Biophys., vol. 13, pp. 75-84 (1992).
Speiss et al., “Sequence of Human Asialoglycoprotein Receptor cDNA,” Journal of Biological Chemistry 260 (4) pp. 1979-1982 (1985).
Sugimoto et al., “Expression of Functional CD40 in Human Hepatocellular Carcinoma,” Hepatology, 30(4) pp. 920-926 (1999).
Sumida et al., “Quantitative Analysis of Constitutive and Inducible CYPs mRNA Expression in the HepG2 Cell Line Using Reverse Transcription-Competitive PCR,” Biochemical and Biophysical Research Communications 267, 756-760 (2000).
Wang et al. (“In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines,” Arch Biochem Biophys 287(1): 186-94 (1991).
Wang et al., “Lipid and lipoprotein metabolism in Hep G2 cells,” Biochim Biophys Acta 961 (3): 351-63; Aug. 12, 1988.
Zeiger et al., “Inducing Effects of Dioxin-like Polychlorinated Biphenyls on CYP1A in the Human Hepatoblastoma Cell Line HepG2, the Rat Hepatoma Cell Line H4IIE, and Rat Primary Hepatocytes: Comparison of . . . ,” Toxicological Sciences, 63, 65-73 (2001).
Zhou et al., “Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis,” Cancer Res., 57 (13): 2749-53, Jul. 1997.
Bchini et al., “In Vitro Infection of Human Hepatoma (HepG2) Cells with Hepatitis B Virus,” Journal of Virology, vol. 64, No. 6, p. 3025-3032 (1990).
Garson et al., “Suramin Blocks Hepatitis C Binding to Human Hepatoma Cells In Vitro,” Journal of Medical Virology, 57, pp. 238-242 (1999).
LeSeyec et al., “Infection Proces of the Hepatitis B Virus Depends on the Presence of a Defined Sequence in the Pre-S1 Domain,” Journal of Virology, vol. 73, No. 3, pp. 2052-2057 (1999).
El Hag et al., “Liver morphology and function in visceral leishmaniasis (Kala-azar),” J. Clin. Pathol, 47: pp. 547-551 (1994).
Nomura et al., “Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation,” Biochimica et Biophysica Acta 1453, pp. 330-340 (1999).
Saeed et al., “Serum erythropoietin concentration in anaemia of visceral leishmaniasis (kala-azar) before and during antimonial therapy,” British Journal of Haematology, 100, pp. 720-724 (1998).
McCoy et al., “N-Formylpeptide and Complement C5a Receptors Are Expressed in Liver Cells and Mediate Hepatic Acute Phase Gene Regulation,”. Exp Med, vol. 182, pp. 207-217 (1995).
Muller et al., “Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes,” The EMBO Journal, vol. 12, No. 7, pp. 2881-2889 (1993).
XMWang et al., “Effects of 5-Azacytidine and Butyrate on Differentiation and Apoptosis of Hepatic Cancer Cell Lines,” Annals of Surgery, vol. 227, No. 6, pp. 922-921 (1998).
Marianneau et al., “Differing Infection Patterns of Dengue and Yellow Fever Viruses in a Human Hepatoma Cell Line,” The Journal of Infectious Diseases, 178, pp. 1270-1278 (1998).
S.R. Wang et al (Biochimica et Biophysica Acta 961:351-363, 1998).
Chiu et al (Hepatology 11(5):834-842, May 1990).
Nomura et al (Biochimica et Biophysica Acta 1453:330-340, 1999).
Le Seyec et al (Journal of Virology 73:2052-2057, 1999).
Germi et al (Journal of Medical Virology 64:6-12, 2001).
Hollingdale et al (Journal of Immunology 132:909-913, 1984).
Saito et al (Cancer Biochemistry Biophysics 13:75-84, 1992).
Karnasuta et al (American Journal of Tropical Medicine and Hygiene 53: 607-11, 1995).
Gripon, Philippe et al., “Regulation by Dimethylsulfoxide, Insulin, and Corticosteroids of Hepatitis B Virus Replication in a Transfected Human Hepatoma Cell Line,” 28(3) Journal of Medical Virology 193-199 (Feb. 1989).
Lian, Wei-Nan et al., “Targeting of Aminopeptidase N to Bile Canaliculi Correlates With Secretory Activities of the Developing Canalicular Domain” 30(3) Hepatology 748-760 (Sep. 1999).
Chiu, Jen-Hwey et al., “The Formation of Bile Canaliculi in Human Hepatoma Cell Lines,” 11(5) Hepatology 834-842 (May 1990).
Neurath, A. Robert et al., “Search for Hepatitis B Virus Cell Receptors Reveals Binding Sites for Interleukin 6 on the Virus Envelope Protein,” 175 J. Exp. Med. 461-469 (Feb. 1992).
Saito, Hidetsugu et al., “Effect of Dexamethasone, Dimethylsulfoxide and Sodium Butyrate on a Human Hepatoma Cell Line PLC/PRF/5,” 13 Cancer Biochemistry Biophysics 75-84 (Nov. 1992).
Zvibel, Isabel et al., “Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents,” 63 Differentiation 215-223 (1998).

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