Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-01-30
2007-01-30
Chernyshev, Olga N. (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C536S023500
Reexamination Certificate
active
09767597
ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
REFERENCES:
patent: WO 00/29448 (2000-05-01), None
patent: WO 00/29448 (2000-05-01), None
EMBL Online, Database Accession No. AI571225, visited on Oct. 29, 2002.
Frings, S. et al. “Characterization of ether-á-go-go channels present in photoreceptors reveals similarity to IKx, a K+current in rod inner segments,”J. Gen. Physiol. Apr. 1998, pp. 583-599, vol. 131.
GENESEQ Online, Database Accession No. AAA6205 Feb. 2, 2001 (Acquired from Derwent).
GENESEQ Online, Database Accession No. AAB12147, visited on Nov. 4, 2002.
Jegla, T. et al. “Cloning and expression of a novel hyperpolerization-activated cation channel, human HCN3,”Society for neuroscience Abstracts, 29th Annual Meeting; Miami Beach, Florida, USA Oct. 23-28, 1999, p. 1, Abstract No. 893.6.
Ludwig, A. et al. “Two pacemaker channels from human heart with profoundly different activation kinetics,”EMBO J.May 4, 1999, pp. 2323-2329, vol. 18, No. 9.
Santoro, B. and Tibbs, G.R. “The HCN gene family: molecular basis of the hyperpolerization-activated pacemaker channels,”Annals of the New York Academy of SciencesApr. 30, 1999, pp. 741-764, vol. 868.
SWALL Online, Database Accession No. 018965, visited on Oct. 29, 2002.
Ludwig, et al., “A family of hyperpolarization-activated mammalian cation channels”;Nature, vol. 393, p. 587-591, (Jun. 1998).
Santoro, et al., “Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels”,Proc. Natl. Acad. Sci. USA, vol. 94, p. 14815-14820 (Dec. 1997).
Santoro, et al., “Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain”;Cell, vol. 93, p. 717-729, (May 1998).
Chernyshev Olga N.
Icagen, Incorporated
Townsend and Townsend / and Crew LLP
LandOfFree
Human HAC3 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human HAC3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human HAC3 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3787317