Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-12-26
2006-12-26
Chernyshev, Olga N. (Department: 1649)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S252300, C536S023100, C536S023500, C530S350000
Reexamination Certificate
active
07153668
ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
REFERENCES:
patent: WO 00/29448 (2000-05-01), None
patent: WO 00/29448 (2000-05-01), None
Ludwig et al., 1998, Nature, 393, pp. 587-591.
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Santoro, et al., “Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain”;Cell, vol. 93, p. 717-729, (May 1998).
Frings, S. et al. “Characterization of ether-à-go-go channels present in photoreceptors reveals similarity to IKx, a K+current in rod inner segments,”J. Gen. Physiol. Apr. 1998, pp. 583-599, vol. 131.
Jegla, T. et al. “Cloning and expression of a novel hyperpolerization-activated cation channel, human HCN3,”Society for neuroscience Abstracts, 29th Annual Meeting; Miami Beach, Florida, USA Oct. 23-28, 1999, p. 1, Abstract No. 893.6.
Ludwig, A. et al. “Two pacemaker channels from human heart with profoundly different activation kinetics,”EMBO J. May 4, 1999, pp. 2323-2329, vol. 18, No. 9.
Santoro, B. and Tibbs, G.R. “The HCN gene family: molecular basis of the hyperpolerization-activated pacemaker channels,”Annals of the New York Academy of SciencesApr. 30, 1999, pp. 741-764, vol. 868.
Chernyshev Olga N.
Icagen, Incorporated
Townsend and Townsend / and Crew LLP
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