Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1993-05-25
1996-07-09
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
435 694, C07K 1461, A61K 3825, C12P 2106
Patent
active
055346170
ABSTRACT:
Human growth hormone variants are disclosed wherein the lysine at position 41 and/or the leucine at position 45 of native human growth hormone, numbered from the mature N-terminus of native human growth hormone, has been replaced with another amino acid. Also claimed are combination variants that have a higher binding affinity to the growth hormone receptor than wild-type human growth hormone.
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Wells, J. A. et al., Philos. T
Cunningham Brian C.
Lowman Henry
Wells James A.
Carlson K. Cochrane
Genentech Inc.
Haliday Emily M.
Terlizzi Laura
Wax Robert A.
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