Human growth hormone DNA

Details Human growth hormone DNA Human growth hormone DNA

1987-04-13

1990-02-06

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Vector, per se

4351723, 935 13, 536 27, C12N 100, C12N 1500

Patent

active

048988308

ABSTRACT:
Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.

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Itakwa et al, Science, vol. 198, pp. 1056-1063, Dec. 1977.
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Seeburg et al, Nature, vol. 276, pp. 795-798, Dec. 1978.
Villa-Komanoff et al, PNAS USA, vol. 75, pp. 3727-3731, Aug. 1978.

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