Human growth hormone-containing aqueous pharmaceutical compositi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, 514 8, 530324, 530351, 530380, 530395, 530397, 530399, 530829, 435 691, A61K 3827

Patent

active

061503312

ABSTRACT:
Provided is an aqueous pharmaceutical composition comprising human growth hormone wherein said human growth hormone is dissolved in a benzalkonium chloride-containing, slightly to weakly acidic solution buffered, most preferably, with maleate. The composition is sufficiently stable to be supplied in liquid state and can be prepared as a less painful composition.

REFERENCES:
patent: 5763394 (1998-06-01), O'Connor et al.
Becker et al., Biotechnology and Applied Biochemistry, vol. 9, pp. 478-487 (1987).
Becker et al., Biotechnology and Applied Biochemistry, vol. 10, pp. 326-337 (1988).

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