Human gp130 protein

Details Human gp130 protein Human gp130 protein

1990-08-02

1992-07-21

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

530350, 53038822, C07K 1300

Patent

active

051324032

ABSTRACT:
Human gp130 protein having at least the following properties: (1) the protein has an affinity with a complex of IL-6 (interleukin-6) and an IL-6 receptor (interleukin-6 receptor); (2) the protein shows an apparent molecular weight of 130 kDa in SDS-polyacrylamide electrophoresis; and (3) the protein participates in the transmission of IL-6 signal; DNA coding for the protein, an expression plamid containing the DNA; and a process for production of the protein using the expression plasmid.

REFERENCES:
Schwabe et al. Lymphokine Res. 9(4): 550 (1990).
Schwabe et al. Progress in Leukocyte Biology 10A (1989).
Faseb, vol. 4, No. 7, Apr. 26, 1990, p. A1918, Abstract No. 1311, Hibi et al.
Taga et al., Cell, vol. 58, No. 3, Aug. 11, 1989, pp. 573-581.
J. M. Short et al., Nucleic Acids Research, vol. 16, No. 15, Aug. 11, 1988, pp. 7583-7600.
T. Taga et al., Cold Spring Harbor Symposia on Quantitative Biology, vol. 54, No. 2, 1989, pp. 713-722.
R. A. Young et al., Proc. Natl. Acad. Sci., vol. 80, No. 5, Mar. 1983, pp. 1194-1198.
Kishimoto, "The Biology of Interleukin-6", Jour. Am. Soc. of Hematology, 74(1): 1-10 (1989).
Kishimoto, "Molecular Regulation of B Lymphocyte Response", Ann. Rev. Immunol., 6: 485-512 (1988).

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