Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1995-09-07
1999-02-23
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4352523, 43525233, 435365, 536 231, 536 232, 536 235, C12N 910, C12N 120
Patent
active
058742719
ABSTRACT:
A gene encoding human glycosyltransferase (human GnT-III) and recombinant DNA method for producing the enzyme are provided. A cancerous metastasis inhibitor comprising GnT-III, or a gene thereof, and a method of inhibiting cancerous metastasis in a mammal are also provided.
REFERENCES:
J. Boichem, vol. 113, No. 6, Jun. 1993, Tokyo, p. 6920698, Y. Ihara et al., "cDNA Cloning Expression and Chromosomal Localization of Human GnT-III".
J. Biol. Chem., vol. 167, No. 25, 5, Sep. 1992, pp. 18199-18204, A. Nishikawa et al., "Purification, cDNA Cloning and Expression of GnT-III From Rat Kidney".
Biochem, Biophys. Res. Commun., vol. 172, No. 3, 15 Nov. 1990, pp. 1260-1266, H. Nakao et al., "Modulation of Gnt, III, IV, V Activities And . . . ".
Clin. Chim. Acta., vol. 185, No. 3, 15 Dec. 1989, pp. 325-332, K. Ishibashi et al., "GnT-III In Human Serum and Liver and Hepatoma Tissues . . . ".
The Journal of Biological Chemistry, vol. 267. pp. 18199-18204 (1992), "Purification, cDNA Cloning, and Expression of UDP-N-acetylglucosamine: .beta.-D-mannoside .beta.-D-mannoside .beta.-1, 4N-Acetylglucosaminyltransferase III from Rat Kidney".
Ihara Yoshito
Nishikawa Atsushi
Taniguchi Naoyuki
Taniguchi Shun'ichiro
Yoshimura Masafumi
Nasheed Nashaat T.
Takara Shuzo Co. Ltd.
Wax Robert A.
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