Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1998-04-20
2000-09-05
Navarro, Mark
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
530350, A61K 3900, C07K 100
Patent
active
061139041
ABSTRACT:
The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.
REFERENCES:
Johnston, I.G., et al., "Molecular Cloning of a Novel mRNA Using an Antibody Directed Against Synaptic Glycoproteins" J. Neurosci. Res., 32:159-166 (1992) (GI 256933).
Sudhof, T.C., "The synaptic vesicle cycle: a cascade of protein-protein interactions" Nature, 375:645-653 (1995).
Bennett, M.K., et al., "Molecular correlates of synaptic vesicle docking and fusion" Curr. Opin. Neurobiol., 4:324-329 (1994).
Nosten-Bertrand, M., et al., "Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1" Nature, 379:826-829 (1996).
Zhong, Y., et al., "Altered Nerve Terminal Arborization and Synaptic Transmission in Drosophila Mutants of Cell Adhesion Molecule Fasciclin I" J. Neurosci., 15:6679-6687 (1995).
Rose, S.P., "How chicks mkae memories: the cellular cascade from c-fos to dendritic remodelling" Trends Neurosci., 14:390-397 (1991).
Mileusnic, R., et al., "Characterisation of Antibodies Specific for Chick Brain Neural Cell Adhesion Molecules Which Cause Amnesia for a Passive Avoidance Task" J. Neurochem., 64:2598-2606 (1995).
Soulliere, J., et al., "Tyrosine Phosphorylation of Glycoproteins in the Adult and Developing Rat Brain" J. Neurosci. Res., 37:506-514 (1994)
Boss, B.J., et al., Pathophysiology, Library/Media Center, Westminster, CO, McCance and Huether eds, 527-586 (1994).
Lassmann, H., et al., "Synaptic Pathology of Alzheimer's Disease" Ann NY Acad. Sci., 695:59-64 (1993).
Andre, B., et al., (GI 1077162), GenBank Sequence Database (Accession 1077162), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier, L. et al., (GI 1383424) EMBL Database (Accession W73289), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 Oct. 16, 1996.
Hillier, L. et al., (GI 1312668) EMBL Database (Accession W31677), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 Oct. 10, 1996.
Au-Young Janice
Bandman Olga
Hawkins Phillip R.
Hillman Jennifer L.
Incyte Pharmaceuticals Inc.
Navarro Mark
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