Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-08-09
1998-10-13
Caputa, Anthony C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 435 691, 4352523, 530350, 536 235, C12P 2106, C12N 1500, C07K 100, C07H 2104
Patent
active
058210865
ABSTRACT:
The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.
REFERENCES:
Lazar et al (Molecular & Cellular Bio. vol. 8 pp. 1247-1252), Mar. 1988.
Burgess et al (J. of Cell Bio. vol. 111 pp. 2129-2138), Nov. 1990.
Salgaller et al (Cancer. Immuno. Immunother. vol. 39 pp. 105-116), 1994.
Hillier, L. et al., (GI 1383424) EMBL Database (Accession W73289), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 Oct. 16, 1996.
Hillier, L. et al., (GI 1312668) EMBL Database (Accession W31677), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 Oct. 10, 1996
Johnston, I.G., et al., "Molecular Cloning of a Novel mRNA Using an Antibody Directed Against Synaptic Glycoproteins" J. Neurosci. Res., 32:159-166 (1992) (GI 256933).
Sudhof, T.C., "The synaptic vesicle cycle: a cascade of protein-protein interactions" Nature, 375:645-653 (1995).
Bennett, M.K., et al., "Molecular correlates of synaptic vesicle docking and fusion" Curr. Opin. Neurobiol., 4:324-329 (1994).
Nosten-Bertrand, M., et al., "Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1" Nature, 379:826-829 (1996).
Zhong, Y., et al., "Altered Nerve Terminal Arborization and Synaptic Transmission in Drosophila Mutants of Cell Adhesion Molecule Fasciclin I" J. Neurosci., 15:6679-6687 (1995).
Rose, S.P., "How chicks make memories: the cellular cascade from c-fos to dendritic remodelling" Trends Neurosci., 14:390-397 (1991).
Mileusnic, R., et al., "Characterisation of Antibodies Specific for Chick Brain Neural Cell Adhesion Molecules Which Cause Amnesia for a Passive Aviodance Task" J. Neurochem., 64:2598-2606 (1995).
Soulliere, J., et al., "Tyrosine Phosphorylation of Glycoproteins in the Adult and Developing Rat Brain" J. Neurosci. Res., 37:506-514 (1994).
Boss, B.J., et al., Pathophysiology, Library/Media Center, Westminster, Co, McCance and Huether eds, 527-586 (1994).
Lassmann, H., et al., "Synaptic Pathology of Alzheimer's Disease" Ann NY Acad. Sci., 995:59-64 (1993).
Andre, B., et al., (GI 1077162), GenBank Sequence Database (Accession 1077162), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Au-Young Janice
Bandman Olga
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Caputa Anthony C.
Incyte Pharmaceuticals Inc.
Nauarro Mark
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