Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-06-30
2008-08-26
Kosar, Andrew D. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C514S004300, C514S015800, C530S300000, C530S327000, C530S330000, C530S333000
Reexamination Certificate
active
07417028
ABSTRACT:
The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 receptor modulators exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration. The peptides of this invention show desirable pharmacokinetic properties and desirable potency in efficacy models of diabetes.
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Ewing William R.
Haque Tasir Shamsul
Lee Ving G.
Mapelli Claudio
Martinez Rogelio L.
Bergen Briana C.
Bristol--Myers Squibb Company
Carey Brian C.
Kosar Andrew D.
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