Human glandular kallikrein enhancer, vectors comprising the...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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C435S320100

Reexamination Certificate

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06916918

ABSTRACT:
Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery vehicles comprising the enhancers and methods of using the vehicles are also provided. Adenovirus vectors in which one or more genes are under transcriptional control of the enhancers of the invention are also provided. Further provided are methods of using the adenovirus vectors of the invention to confer selective cytotoxicity in mammalian cells.

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