Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1995-06-06
1998-07-28
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
435 691, 4352523, 4353201, 536 232, 536 2431, C12N 910, C12N 1554, C12N 1563, C12N 1579
Patent
active
057861935
ABSTRACT:
A human geranylgeranyl pyrophosphate synthetase polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for controlling morphology of cells. Antagonist against such polypeptides and their use as a therapeutic to treat cancer is also disclosed. Diagnostic assays are also disclosed which detect the presence of a mutated form of hGGPS and over-expression of the hGGPS protein.
REFERENCES:
patent: 5304478 (1994-04-01), Bird et al.
patent: 5420245 (1995-05-01), Brown et al.
patent: 5429939 (1995-07-01), Misawa et al.
patent: 5443978 (1995-08-01), Ellenberger et al.
patent: 5530188 (1996-06-01), Ausich et al.
patent: 5530189 (1996-06-01), Ausich et al.
Sheares, B. T., et al., Biochemistry, vol. 28, "Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells", pp. 8129-8135, 1989.
Wilkin, D. J., et al., The Journal of Biological Chemistry, vol. 265, "Isolation and sequence of the human farnesyl pyrophosphate synthetase c DNA", pp. 4607-4614, 1990.
Kuntz, M., et al., The Plant Journal, vol. 2, "Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsium annuum: correlative increase in enzyme activity and transcript level during fruit ripening", pp. 25-34, 1992.
EMBL nucleotide sequence database Accession No. Z44596, Locus HSC25A041, "H. sapiens partial cDNA sequence; clone c-25a04.", 1994.
GenBank nucleotide sequence database Accession No. R61164, Locus R61164, "yh10f02.rl Homo sapiens cDNA clone 42865 5'", 1995.
GenBank/EST nucleotide sequence database Accession No. T31667, "EST36765 Homo sapiens cDNA 5'end similar to None.", 1995.
Greene John M.
Kirkness Ewen F.
Rosen Craig A.
Human Genome Sciences Inc.
Moore William W.
Mullins J. G.
Olstein Elliot M.
Wax Robert A.
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