Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1996-03-29
1997-10-07
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4352542, 4353201, 435325, 435348, 536 235, 935 64, 935 70, 935 72, C12N 120, C12N 1563, C12N 500, C07H 2104
Patent
active
056747390
ABSTRACT:
The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung, and bone tumors, various types of skin cancers, and other neoplastic conditions such as leukemias and lymphomas. Genes are identified that are differentially expressed in benign (e.g., non-malignant) tumor cells relative to malignant tumor cells exhibiting a high metastatic potential. Genes are also identified via the ability of their gene products to interact with gene products involved in the progression to, and/or aggressiveness of, neoplastic tumor disease states. The genes and gene products identified can be used diagnostically or for therapeutic intervention.
REFERENCES:
patent: 5262321 (1993-11-01), Livingston et al.
patent: 5457049 (1995-10-01), Giordano
patent: 5470970 (1995-11-01), Sager et al.
patent: 5491064 (1996-02-01), Lichy et al.
patent: 5496731 (1996-03-01), Xu et al.
Tanaka et al., "Construction of a Human Cytochrome C Gene and Its Functional Expression in Saccharomyces cerevisiae", J. Biochem., 103:954-961 (1988).
Wilson et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", Nature, 368:32-38, (1994).
PCT Search Report PCT/US96/04413, mailed Jul. 9, 1996.
Fidler, I.J., 1973, "Selection of Successive Tumor Lines for Metastasis," Nature New Biol. 242:148-149.
Fodde, R., et al., 1994, "A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors," Proc. Natl. Acad. Sci. USA 91:8969-8973.
Folkman, J. and Klagsburn, M., 1987, "Angiogenic Factors," Science 235:442.
Hodgkinson, C.A., et al., 1993, "Mutations at the Mouse Microphthalmia Locus Are Associated with Defects in a Gene Encoding a Novel Basic-Helix-Loop-Helix-Zipper protein," Cell 74:395-404.
Karmali, R.A., et al., 1983, "Prostaglandins in breast cancer: Relationship to disease stage and hormoine status," Br. J. Cancer 48:689-696.
Karmali, R.A., et al., 1987, "The Effects of Dietary .omega.-3 Fatty Acids on the DU-145 Transplantable Human Prostatic Tumor," Anticancer Res. 7:1173-1180.
Kozlowski, J.M., et al., 1984, "Metastatic Behavior of Human Tumor Cell Lines Grown in the Nude Mouse," Cancer Research 44:3522-3529.
Leder, A., et al., 1986, "Consequences of widespread deregulation of the C-MYC gene in transgenic mice: multiple neoplasms and normal development," Cell 45:485-495.
Leone, A., et al., 1991, "Reduced Tumor Incidence, Metastatic Potential, and Cytokine Responsiveness of nm23-Transfected Melanoma Cells," 65:25-35.
Liotta, L.A. et al., 1991, "Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation," Cell 64:327.
Mintz, B., and Silvers, W.K., 1993, "Transgenic mouse model of malignant skin melanoma," Proc. Natl. Acad. Sci. USA 90:8817-8821.
Morikawa K., et al., 1988, "In Vivo Selection of Highly Metastatic Cells from Surgical Specimens of Different Primary Human Colon Carcinomas Implanted into Nude Mice," Cancer Research 48:1943-1948.
Qian, F., et al., 1994, "Expression of the Integrin .alpha.4.beta.1 on Melanoma Cells can Inhibit the Invasive Stage of Metastasis Formation," Cell 77:335-347.
Rose, D.P., et al., 1993, "Effects of Dietary Omega-3 Fatty Acids on Human Breast Cancer Growth and Metastases in Nude Mice," J. Natl. Cancer Inst. 85:1743-1747.
Schrier, P.I., et al., 1983, "Expression of Class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells," Nature 305:771.
Steeg, P.S., et al., 1988, "Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential," J. Natl. Cancer Inst. 80:200-204.
Van der Bruggen, P., et al., 1991, "A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma," Science 254:1643-1667.
Vogelstein, B., and Kinzler, K.W., 1993, "The Multistep Nature of Cancer," Trends Genet. 9:138-141.
Watts C.K., et al., 1994, "Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells," Breast Cancer Res. Treat. 31:95-105.
Zou, Z., et al., 1994, "Maspin, A Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells," Science 263:526-529.
Millennium Pharmaceuticals Inc.
Robinson Douglas W.
Wai Thanda
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