Human gamma interferon-specific receptor protein, antibody again

Details Human gamma interferon-specific receptor protein, antibody again Human gamma interferon-specific receptor protein, antibody again

1987-03-27

1990-01-30

Rosenberg, Peter D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

435183, A61K 3900, A61K 4502

Patent

active

048972649

ABSTRACT:
Analysis of [.sup.125 I]. interferon gamma cross-linked to its receptor on various human cells by SDS-PAGE revealed that there are at least three different types of human interferon gamma receptors. In WISH, HeLa, FS11 and the other tissue cells an Mr 90,000-105,000 receptor was found. In monocytes and in the myeloid cell line KG-1 an Mr 140,000 receptor was found while in Daudi lymphoblastoid cells an Mr 95,000-115,000 receptor was found.
The various receptors were isolated from these cells by extraction followed by affinity chromotography on an immobilized interferon gamma column. The resulting purified preparations retained their original affinity for interferon gamma and were used for immunizing mice and subsequent development of highly specific antibodies.

REFERENCES:
patent: 4617378 (1986-10-01), Rubinstein
patent: 4650674 (1987-03-01), Aggarwal
patent: 4751078 (1988-06-01), Nagabhushan

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