Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1989-01-13
1993-02-09
Lacey, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 435 724, 4351722, 43524027, 530350, 5303879, 53038822, 53038875, 536 235, C12P 2106, C12N 502, A61K 3514, C07H 1512
Patent
active
051852500
ABSTRACT:
The present invention is directed to purified polypeptides comprising the .gamma. T cell antigen receptor (TCR) polypeptide, the .delta. TCR polypeptide, a .gamma., .delta. TCR complex, or a fragment thereof containing an epitope. The invention also relates to nucleic acid sequences encoding such polypeptides, and subsequences thereof. In specific embodiments, the invention relates to nucleic acid sequences comprising variable, diversity, joining, or constant regions of the .delta. TCR gene sequence. The invention also relates to monoclonal antibodies specifically reactive with an epitope of the gamma or delta TCR polypeptides. In specific embodiments, these antibodies are reactive with the delta constant region, the delta variable region, or gamma constant region. Such antibodies can be identified by detecting co-modulation of the CD3 antigen. In another embodiment, the invention relates to compositions comprising substantially purified cells which express both a .gamma., .delta. TCR and the CD4 antigen. The invention also relates to a composition comprising cells which express a .gamma., .delta. TCR that is not associated with a CD3 complex.
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Picker et al. Am. J. Pathol. 132:401 (Sep. 1988).
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Satyanarayana et al.; Proc. Natl. Acad. Sci. USA 85:8166 (Nov. 1988).
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Band Hamid
Brenner Michael B.
Ip Stephen H.
Krangel Michael S.
Seidman Jonathan
Dana Farber Cancer Institute
Lacey David L.
President & Fellows of Harvard College
T Cell Sciences, Inc.
Wang Gian P.
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